FVB/NJ-Tg(Ube3a)5Mpan/J

Cat. No.: CEMM-07251067

Common Name: Ube3a-2×(untagged)

Ube3a OFF#5 BAC transgenic mice [also called "Ube3a-2×(untagged)"] express functional, floxed Ube3a protein in addition to endogenous Ube3a. This increased Ube3a expression models maternal 15q11-13 duplication (dup15) and triplication (isodicentric extranumerary chromosome, idic15) that is associated with 1-3% of cases of human autism spectrum disorder.

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Status	Live Mouse Frozen Embryo
Age	4 weeks 12 weeks Customized Age
Sex	Male Female

GENETICS
Allele Symbol	Tg(Ube3a)5Mpan show more close
Allele Name	transgene insertion 5 show more close
Allele Attributes	Inserted expressed sequence show more close
Gene Symbol	Tg(Ube3a)5Mpan show more close
Gene Name	transgene insertion 5 show more close
Chromosome	UN show more close
MGI Accession ID	6754127 show more close
Strain of Origin	FVB/NJ show more close
Molecular Note	The transgenic construct contains the entire ubiquitin protein ligase E3A (Ube3a) gene; it is designed to have a loxp sites flanking exons 3-5. A single FRT site remains just downstream of exon 5 (a remnant of the FRT flanked zeomycin resistance cassette that was removed by a FLP-expressing plasmid during the BAC recombineering). show more close

HUSBANDRY
Suggested Controls	FVB/NJ Noncarrier show more close
Breeding Considerations	Homozygous and hemizygous animals are viable and fertile. Homozygous mice have heightened aggression, while hemizygous mice are not aggressive. When maintaining our live colony, hemizygous animals may be bred to wildtype (non-carrier) mice or to FVB/NJ inbred mice. show more close
Breeding Strategy	Wild-type x Hemizygote; Hemizygote x Noncarrier show more close

For Research Use Only.