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B6N.Cg-Dgcr8tm1.1Blel/Mmjax
Cat. No.: CEMM-07250225
These floxed mutant mice harbor loxP sites flanking exon 3 of the DiGeorge syndrome critical region gene 8 (Dgcr8) gene and may be useful in generating conditional mutations for studying the role of Dgcr8 in microRNA regulation.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Dgcr8tm1.1Blel
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Dgcr8
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| Gene Name |
DGCR8
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| Chromosome |
16
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| MGI Accession ID | show more close |
| Strain of Origin |
(C57BL/6 x 129S4/SvJae)F1
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| Molecular Note |
A loxP site was inserted in intron 2 and a floxed CMV-Hygro selection cassette was inserted in intron 3. ES cells were sequentially targeted so that ES cells carried two mutated alleles. Cre recombinase treatment of these ES cells resulted in two mutant alleles, this one with a floxed exon 3 but lacking the selection cassette and another allele which lacks both exon 3 and the selection cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6NJ
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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