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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6;129S-Grptm1.1(EGFP/cre)Zfc/J (Cat. No.: CEMM-07250947) | Inquiry | |
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GrpCre-KI knock-in/knock-out mice have an enhanced green fluorescent protein sequence (EGFP) fused to a Cre Recombinase sequence (cre) into the ATG start codon of the gastrin releasing peptide (Grp) gene. These mice are useful when for characterizing innervation of Grp sensory neurons and studying the role of Grp spinal neurons in itch and pain.
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| B6.Cg-Igs7tm62.1(tetO-tdTomato)Hze/J (Cat. No.: CEMM-07250477) | Inquiry | |
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These Ai62(TITL-tdT)-D mice (also called Ai62D) are a fluorescent Cre/Tet reporter line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassette by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of tdTomato.
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| B6.Cg-Igs7tm78.1(tetO-VSFPB1.2)Hze/J (Cat. No.: CEMM-07250505) | Inquiry | |
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Ai78(TITL-VSFPB)-D (also called Ai78D) mice are a Cre/Tet-dependent, voltage-sensitive, fluorescent line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassette by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of the voltage-sensitive fluorescent protein Butterfly 1.2 (VSFP-Butterfly1.2 or VSFPB1.2). VSFP-Butterfly1.2 exhibits voltage-dependent FRET upon membrane depolarization, and enables optical recordings at high spatial resolution with intrinsic assignment of recorded signals to VSFP-targeted cell populations (such as layer 2/3 pyramidal cells).
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| B6;129S-Igs7tm82.1(tetO-EGFP)Hze/J (Cat. No.: CEMM-07250508) | Inquiry | |
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Ai82(TITL-EGFP)-D (also called Ai82D) mice are a Cre/Tet-dependent, fluorescent reporter line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassette by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of EGFP.
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| B6.Cg-Igs7tm90.1(tetO-COP4*/EGFP)Hze/J (Cat. No.: CEMM-07250523) | Inquiry | |
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Ai90(TITL-Chronos)-D (also called Ai90D) mice are a Cre/Tet-dependent, optogenetic line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Following Cre-mediated removal of the STOP cassette, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of the channelrhodopsin/EGFP fusion protein (Chronos/EGFP). Subsequent illumination of Chronos-expressing (EGFP fluorescent) cells with blue-to-green light leads to reversible photostimulation of action potential firing/neural activity in these cells.
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| B6;129S6-Igs7tm93.1(tetO-GCaMP6f)Hze/J (Cat. No.: CEMM-07250525) | Inquiry | |
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Ai93(TITL-GCaMP6f)-D (also called Ai93D) mice are a Cre/Tet-dependent, fluorescent calcium indicator line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassettes by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of GCaMP6 fast variant calcium indicator (GCaMP6f; a detector of single neuronal action potentials with fast response kinetics). Following subsequent calcium binding (such as neuronal activation), bright EGFP fluorescence is observed.
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| B6;129S-Gt(ROSA)26Sortm95.1(CAG-GCaMP6f)Hze/J (Cat. No.: CEMM-07250527) | Inquiry | |
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This Ai95D allele is available on a C57BL/6J genetic background as; which replaced this mixed background strain.Ai95(RCL-GCaMP6f)-D (also called Ai95D) mice are a Cre-dependent, fluorescent, calcium-indicator tool strain. Ai95D has a floxed-STOP cassette preventing transcription of the GCaMP6 fast variant calcium indicator (GCaMP6f; a detector of single neuronal action potentials with fast response kinetics). After Cre exposure, bright EGFP fluorescence is observed following calcium binding (such as neuronal activation).
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| B6;129S6-Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/J (Cat. No.: CEMM-07250528) | Inquiry | |
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This Ai96 allele is available on a C57BL/6J genetic background as and that version will replace this mixed background strain in the future. Ai96(RCL-GCaMP6s) (also called Ai96) mice are a Cre-dependent, fluorescent, calcium-indicator tool strain. Ai96 has a floxed-STOP cassette preventing transcription of the GCaMP6 slow variant calcium indicator (GCaMP6s; an ultrasensitive detector of single neuronal action potentials with slower decay and response kinetics). After Cre exposure, increased EGFP fluorescence is observed following calcium binding (such as neuronal activation).
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| B6J.Cg-Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/MwarJ (Cat. No.: CEMM-07250705) | Inquiry | |
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Ai96(RCL-GCaMP6s) (also called Ai96) mice are a Cre-dependent, fluorescent, calcium-indicator tool strain. Ai96 has a floxed-STOP cassette preventing transcription of the GCaMP6 slow variant calcium indicator (GCaMP6s; an ultrasensitive detector of single neuronal action potentials with slower decay and response kinetics). After Cre exposure, increased EGFP fluorescence is observed following calcium binding (such as neuronal activation).
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| B6.Cg-Igs7tm92.1(tetO-ECFP*/Venus*)Hze/J (Cat. No.: CEMM-07250594) | Inquiry | |
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Ai92(TITL-YCX2.60)-D (also called Ai92D) mice are a Cre/Tet-dependent, fluorescent calcium indicator line, created by targeted insertion of floxed-STOP-YCX2.60 at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassettes by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of a FRET-based Ca2+ sensor with expanded dynamic range (YCX2.60). Following subsequent calcium binding (such as neuronal activation), robust yellow fluorescence and diminished cyan fluorescence is observed.
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For Research Use Only.