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B6.Cg-Arctm1.1Rpa/J
Cat. No.: CEMM-07250946
Common Name: Arclox
The entire coding region of the mouse Arc (activity regulated cytoskeletal-associated protein) gene is flanked by loxP sites in this Arclox conditional mutant strain. Cre-mediated excision of the floxed region in exon 1 creates a knock-out allele. Inactivation of Arc, involved in memory consolidation, prevents establishment of a strong conditional taste aversion that can develop as a consequence of food poisoning or chemotherapy treatment.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Arctm1.1Rpa
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Arc
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| Gene Name |
activity regulated cytoskeletal-associated protein
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| Chromosome |
15
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| MGI Accession ID | show more close |
| Strain of Origin |
(129S6/SvEvTac x C57BL/6NCrl)F1
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| Molecular Note |
A loxP site was introduced to the promoter region and a loxP-FRT neomycin-FRT cassette was placed in the first intron downstream of the first exon. Flp-mediated recombination removed the FRT flanked neo cassette leaving the coding region floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Heterozygous and homozygous floxed mice are viable and fertile.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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